Although the series has a good standing as a romance-comedy, there are a few underlying elements that I think is kinda a bit...odd... or off. First of all, there are all this talk about "real love" and "emotional bond", when the love sickness rooted from tasting...saliva? You might get this impresion at first, but their feelings for one another did blossom within the course of their relationship. Second, Mikoto wanted Akira to be faithful to her, while she goes out sampling out guys to share this bond with. This also goes far as insisting her feelings and thoughts should trump over her partner's. It took the insight of the girlfriend of Akira's best friend to make Mikoto think about Akira's feelings and thoughts. But things do get better farther along the story when Mikoto starts to take into consideration what Akira feels about the whole thing.
Oddly one-sided relationship tropes aside, I do get a bit queasy on the sharing saliva everyday as a prevention for fever induced love sickness thing. Throughout viewing this series, I got to think that this might be an ideal love-comedy thing to get into for those with light "bodily fluid" fetishes.